Expression and distribution of cell-surface proteoglycans in the normal Lewis rat molar periodontium

Wilairat Worapamorn, D. of Conservative Dentistry, F. of Dentistry, PSU.
Li, H., Connective Tissue Research Lab, D. of Dentistry, The U. of Queensland, Australia
Pujic, Z., Connective Tissue Research Lab, D. of Dentistry, The U. of Queensland, Australia
Xiao, Y., Connective Tissue Research Lab, D. of Dentistry, The U. of Queensland, Australia
Young, W.G., Assoc. Prof., D. of Dentistry, The U. of Queensland, Australia
Bartold, P.M., Prof., D. of Dentistry, The U. of Queensland, Australia
Corresponding e-mail : wwilaira@ratree.psu.ac.th

Published : J. of Periodontal Research, 35 : 214-224, 2000
Key words : periodontium, syndecan-1, syndecan-2, syndecan-4, glypican, betaglycan

Cell-surface proteoglycans participate in several biological functions such as cell-cell and cell-matrix interactions, cell adhesion, the binding to various growth factors as co-receptors, and repair. To better understand the expression and distribution of cell-surface proteoglycans in the periodontal tissues, an immunohistochemical evaluation of the normal Lewis rat molar periodontium using panels of antibodies for syndecan-1, -2, -4, glypican and betaglycan was carried out. Our results demonstrated the expression and distribution of all proteoglycans in the suprabasal gingival epithelium, soft and hard connective tissues. Both cellular and matrix localization was evident within the various periodontal compartments. The presence of these cell-surface proteoglycans indicates the potential for roles in the process of tissue homeostasis, repair or regeneration in periodontium of which each function requires further study.

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