The effects of inhaled corticosteroid to height standard deviation score in
asthmatic children
Nitayada Siriwaradon, D. of Pediatrics, F. of Medicine, PSU.
Pasuree Sangsupawanich, D. of Pediatrics, F. of Medicine, PSU.
Somchit Jaruratanasirikul, Assoc. Prof., D. of Pediatrics, F. of Medicine, PSU.
Grant : RTG-WHO and Faculty of Medicine, PSU.
Presented : The 16th Annual Academic Meeting, Faculty of Medicine, PSU, Hat Yai, Songkhla,
16-18 August 2000
Key words : inhaled corticosteroid, asthmatic children
Background : Inhaled corticosteroid has been used increasingly in treatment of asthma to re-duce airway hyperresponsiveness and inflammation. Systemic corticosteroid has been proved to have adverse effects on height. However the inhaled corticosteroid is controversial.
Objective : To study the effects of inhaled corticosteroid to the height standard deviation score (HSDS) in asthmatic children.
Study design : Retrospective study.
Methods : This study reviewed the records of prepuberty asthmatic children who attended
chest clinic in Songklanagarind Hospital between 1997-1999. The median age of the sample was 3.9 years with range between 7 months to 10 years and the mean follow up period was about 1.5 years
after first visit.
Results : Records of 133 patients were reviewed. One hundred and twelve patients inhaled corticosteroid. Twenty-one patients did not inhale this medication. Twenty-eight percent of the pa-tients used inhaled corticosteroid 201-400 mg daily whereas 23% used below 200 mg/d. After com-mencing inhaled corticosteroid, the reduction in HSDS was not statistically significant. (p<0.05).
The number of exacerbation, systemic corticosteroid was not related to growth retardation.
Conclusion : The administration of inhaled corticosteroid to prepubertal children had no ad-verse effects on height.
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