Evaluation of methylcellulose and carbopol solutions as viscous vehicles for ketoconazole ophthalmic suspensions
การประเมินสารละลายเมทิลเซลลูโลสและสารละลายคาร์โบปอล เพื่อเป็นน้ำกระสายยาที่หนืด
สำหรับยาแขวนตะกอนทางตา
Arunsri Sunthornpit, Asst. Prof., D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Nattha Kaewnopparat, Asst. Prof., D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Supreedee Songkarak, D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Damrongsak Fahroongsarng, Asst. Prof., D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Corresponding e-mail : sarunsri@ratree.psu.ac.th
Grant : Prince of Songkla University
Published : Songklanakarin J Sci Technol 2000, 22(4) : 435-445
Key words : ketoconazole, ophthalmic suspension, methylcellulose, carbopol
Methycellulose 4000 (MC 4000) and Carbopol 940 (CP 940) were evaluated as the suspend-
ing agent of choice for extemporaneous 2%w/v ketoconazole ophthalmic suspension, either from powders or from pulverized commercial tablets. Primarily, the sedimentation volume, redispersibility, dense of sediment, and pourability studies revealed the optimum levels of 0.75 and 0.05% w/v for
MC 4000 and neutralized CP 940, respectively. Suspensions with the described levels of the exci-
pients were prepared and subjected to study on their properties as well as fungal susceptibility during storage at room temperature, 5oC and 50oC for up to 12 weeks. MC 4000 suspensions exhibited deflocculated system so that the viscosity decreased with increasing temperature whereas those with CP 940 approached flocculated suspension so that the viscosity behaved in the opposite direction. At a high temperature, chemical instability of formulations was suspected since their supernatant slightly changed in color with time. Microbial susceptibility of the drug in suspensions prepared by both MC 4000 and CP 940 was within the recommended range but reduced with time especially when stored
at high temperature. MC 4000 with appropriate storage conditions could be used as an ophthalmic vehicle for microfine ketoconazole whereas CP 940 could not because of flocculation.
BACK