Lawsone methyl ether in oral base and its chemical stability

Lawsone methyl ether in oral base and its chemical stability
ลอว์โซนเมธิลอีเธอร์ในออรัลเบสและความคงตัวทางเคมี

Pharkphoom Panichayupakaranant, D. of Pharmacognosy and Pharmaceutical Botany, F. of Pharmaceutical Sci., PSU.
Supreeya Yuenyongsawad, D. of Pharmacognosy and Pharmaceutical Botany, F. of Pharmaceutical Sci., PSU.
Wantana Reanmongkol, Assoc. Prof., D. of Clinical Pharmacy, F. of Pharmaceutical Sci., PSU.

Published : Songklanakarin J Sci Technol 2000, 22(4) : 523-527
Key words : lawsone methyl ether, 2-methoxy-1,4-naphthoquinone, SCMC oral base, antifungal, Candida albicans

An antifungal naphthoquinone, lawsone methyl ether, was semisynthesized by methylation of lawsone. It exhibited low acute toxicity with LD₅₀ of 70.7 mg/kg upon intraperitoneal administration in mice. An oral preparation of 0.5% lawsone methyl ether in sodium carboxymethyl cellulose oral base, appeared to be stable under heating-cooling cycle test. In vitro evaluation of antifungal activity against Candida albicans showed that the activity of 0.5% lawsone methyl ether preparation was similar to that of 1.0% clotrimazole cream.

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