Intravenous gamma globulin for treatment of chronic idiopathic thrombo-cytopenic purpura in children
การรักษาเด็กที่เป็นโรคเกร็ดเลือดต่ำที่ไม่ทราบสาเหตุชนิดเรื้อรังด้วยการให้แกมม่าโกลบูลิน
ทางหลอดเลือดดำ
Vichai Laosombat, Prof., D. of Pediatrics, F. of Medicine, PSU.
Aranya Wiriyasateinkul, Nurse, D. of Pediatrics, F. of Medicine, PSU.
Malai Wongchanchailert, Asst. Prof., D. of Pediatrics, F. of Medicine, PSU.
Corresponding e-mail : lvichai@ratree.psu.ac.th
Grant : Government Budget
Published : J Med Assoc Thai 2000, 83 : 160-168
Key words : immunoglobulin, gamma globulin, chronic ITP, children
A prospective and descriptive study was carried out in 17 children with chronic ITP. Five-day course of Intraglobin (400 mg/kg/d x 5) was given intravenously to 10 children with the age of 4-16 years (5 males and 5 females). Two-day course of Venoglobulin-I (1 g/kg/d x 2) was given intra-venously to 7 children with the age f 3-15 years (3 males and 4 females). Intraglobin and Venoglo-
bulin-I were effective in treating children with chronic ITP. All of the patients had transient increased in their platelet counts during the first 2 weeks. The two-day course of Venoglobulin-I was superior
to the five-day course of Intraglobin. Mild adverse effects were observed in a greater percentage of patients treated by Venoglobulin-I than in patients treated by Intraglobin. Intravenous immunoglobu-lin was one of the choices of treatment in children with chronic ITP, but the cost of immunoglobulin or gamma globulin is quiet high.
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