Factors related to advanced stage oral squamous cell carcinoma
ปัจจัยที่เกี่ยวข้องกับสแควมัสเซลล์คาร์ซิโนมาของช่องปากในระยะท้าย
Duangporn Kerdpon, Asst. Prof., D. of Stomatology, F. of Dentistry, PSU.
Hutcha Sriplung, Assoc. Prof., D. of Pathology, F. of Medicine, PSU.
Corresponding e-mail : kduangpo@ratree.psu.ac.th
Published : J Dent Res 2000, 79 (Special Issue) : 238
Presented : International Association for Dental Research, April 5-8, 2000, Washington, DC,
USA.
Key words : oral squamous cell carcinoma, diagnosis, prognosis
A critical factor that indicates a poor prognosis of oral squamous cell carcinoma (OSCC) is advanced stage disease. The study, therefore, aimed to identify the factors related to advanced stage (TNM staging III, IV) OSCC. There were 161 patients with squamous cell carcinoma of the oral cavity and lip (ICD-9 140, 141, 143-5), included in the study. Sixty two percent of the patients presented
with advanced stage disease. Information on demographic characteristics, risk habits, health seeking behaviour prior to diagnosis, tumour characteristics and patient and professional delay was obtained by questionnaire and these variables included as initial variables in a logistic regression to calculate
the odds ratio (OR) of advanced versus early stage OSCC. Having traditional herbal medication before health professional consultation was the only factor that significantly increased the risk of advanced stage OSCC (OR 5.77; 95% CI 1.25-26.62). Floor of mouth was associated with a lower risk of ad-vanced stage disease (OR 0.27; 95% CI 0.09-0.82). The findings indicate that having traditional herbal medication before health professional consultation increased the risk of advanced stage disease. The lower risk of advanced stage OSCC associated with ulcerative tumours and those on the floor of the mouth may be due to their being more readily detected by the patients.
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