Comparison of p53 protein expression in oral carcinomas associatedwith betel chewing, with oral carcinomas associated with smoking

Comparison of p53 protein expression in oral carcinomas associatedwith betel chewing, with oral carcinomas associated with smoking
การเปรียบเทียบการแสดงออกของโปรตีนพี 53 ในมะเร็งคาซิโนมาของช่องปากกลุ่มที่มี ความเกี่ยวข้องกับการเคี้ยวหมากและกลุ่มที่เกี่ยวข้องกับการสูบบุหรี่

Duangporn Kerdpon, Asst. Prof., D. of Stomatology, F. of Dentistry, PSU.
Hutcha Sriplung, Assoc. Prof., D. of Pathology, F. of Medicine, PSU.
Suparp Kietthubthew, D. of Stomatology, F. of Dentistry, PSU.
Corresponding e-mail : kduangpo@ratree.psu.ac.th

Grant : Prince of Songkla University
Published : Research Report
Key words : p53, immunohistochemistry, oral squamous cell carcinomas, betel quid, tobacco smoking, alcohol drinking, smokeless tobacco

Tobacco smoking and alcohol drinking are the principal factors associated with p53 expression in oral squamous cell carcinomas (OSCC) in the west, whereas betel quid chewing and smokless tobacco are important factors in the east. Variable results of p53 expression have been reported and it has been proposed that ethnic difference and a variation in the indigenous oral habit may be respon-sible for the finding. This study therefore investigated p53 expression among 106 OSCC patients from a southern Thailand population in which all 4 risks behaviours, tobacco smoking, alcohol drinking, betel quid chewing and use of smokless tobacco, are practised. The association of p53 expression with lifetime exposure to each risk behaviour were explored. Multivariate modelling showed that lifetime exposure to alcohol drinking was significant positively associated with p53 expression (like-lihood ratio p value 0.01). Betel quid chewing and tobacco smoking habit showed a trend of de- creasing risk of p53 expression with increased lifetime exposure (OR 0.62, 95% CI 0.39-1.00 and OR 0.50, 95% CI 0.26-0.98, respectively). No significant association was found between p53 expression and clinico-pathological parameters. Further investigations are needed to study 1) the molecular alteration of p53 in each risk habit and 2) other possible pathways of oral carcinogenesis in betel quid- and tobacco smoking-associated OSCC in these group of patients.

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