Investigation of the diuretic effect of Ananas comosus rhizome extract in rat
การทดสอบสรรพคุณในการเป็นยาขับปัสสาวะของเหง้าสับปะรดในหนูขาว
Siriphun Hiranyachattada, D. of Physiology, F. of Sci., PSU.
Suparp Nualplub, D. of Physiology, F. of Sci., PSU.
Supreeya Yuenyongsawad, D. of Pharmacognosy and Pharmaceutical Botany,
F. of Pharmaceutical Sci., PSU.
Corresponding e-mail : hsiriphu@ratree.psu.ac.th
Grant : The Ministry of Public Health, Thailand and UNICEF
Published : Songklanakarin J Sci Technol 2000, 22(2) : 199-207
Key words : diuretic, Ananas comosus, GFR, sodium excretion
The effects of crude water-extract of pineapple (Ananas comosus) rhizome on urinary excretion was investigated in rats using clearance technic. The extract contains sodium and potassium ranging from 0.8-1.5 and 0.025-0.6 mEq/g of dry weight, respectively. No lethal effect was detected after oral administration at the dose as high as 20g/kg body weight. There were no changes in plasma concentration of sodium and potassium after 15 days daily feeding of the extract at the dose of 2.5g/kg body weight per day. Investigation of the diuretic effect was performed in unconscious rats. The animals were previously fed at the doses of 0.125 and 2.5 g/kg body weight. Furosemide 0.125g/kg body weight was used as a positive diuretic control. Urinary excretory function, including urine flow rate, sodium and potassium excretion rate and glomerular filtration rate (GFR), were determined. There were no changes in urine flow rate, GFR, or sodium and potassium excretion rate in rats re-ceiving crude extract orally compared with furosemide. Further studies need to be done to confirm
the lack of diuretic effect.
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