Stability of extemporaneous norfloxacin suspension
Prapaporn Boonme, D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Narubodee Phadoongsombut, D. of Pharmaceutical Chemistry, F. of Pharmaceutical Sci., PSU.
Parichat Phoomborplub, 5th year Pharmacy Student, PSU.
Supavalee Viriyasom, 5th year Pharmacy Student, PSU.
Corresponding e-mail : bprapapo@ratree.psu.ac.th
Grant : Faculty of Pharmaceutical Sciences, PSU
Published : Drug Dev Ind Pharm 2000, 26(7) : 777-779
Key words : norfloxacin, suspension, stability
The stability of norfloxacin as extemporaneous suspensions compounded from two brands of film-coated tablets (formulas I and II) was studied. The vehicle consisted of tragacanth, saccharin sodium, sorbitol solution, glycerin, paraben concentrate, peppermint spirit BP, purified water and
syrup USP. The final concentration of norfloxacin in the suspensions was 20 mg/ml. Formulas I and II were chemically stable for 28 days when stored in amber glass bottles at ambient temperature; however, their physical characteristics were different.
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