Rheological characteristics and dissolution profiles of norfloxacin suspension

Prapaporn Boonme, D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Narubodee Phadoongsombut, D. of Pharmaceutical Chemistry, F.of Pharmaceutical Sci., PSU.
Suthimaln Ingkatawornwong, D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Damrongsak Fahroongsarng, Asst. Prof., D. of Pharmaceutical Tech., F. of Pharmaceutical Sci., PSU.
Corresponding e-mail : bprapapo@ratree.psu.ac.th

Grant : Prince of Songkla University
Presented : The 18th FAPA Conference, Sydney, Austrlia, 27-30 October 2000, p.100
Key words : norfloxacin, suspension, dissolution, rheology

Norfloxacin suspension (100-mg/5 ml) was formulated for the purpose of using in the patients who have difficulty swallowing solid dosage forms. It was prepared by levigating norfloxacin powder with glycerin to form a paste, and then adding paraben concentrate, sodium chloride solution, sodium saccharin solution, and sufficient purified water. The product was a white suspension with high sedi-mentation volume and pH of 7.43±0.04 (n=6). Its rheograms showed the plastic flow with thixotropic property. The USP dissolution testing of norfloxacin tablets was modified to investigate the dis-solution profiles of norfloxacin suspension and of raw material. Although there was no significant difference, the average of the percentage of drug dissolved from the suspension was lower than the raw material alone. These results were probably due to the aggregation or flocculation of the drug particles in the suspension.

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