In Vitro elution characteristics of antibiotic cement on MRSA organism

Boonsin Buranapanitkit, Asst. Prof., D. of Orthopaedic Surgery and Physical Medicine, F. of Medicine, PSU.
Suntorn Wongsiri, D. of Orthopaedic Surgery and Physical Medicine, F. of Medicine, PSU.
Natnicha Ingviya, Microbiology Unit, D. of Pathology, F. of Medicine, PSU.
Alan Geater, Epidemiology Unit, F. of Medicine, PSU.
Apiradee Lim, Epidemiology Unit, F. of Medicine, PSU.
Sineenart Kalnauwakul, Asst. Prof., D. of Pathology, F. of Medicine, PSU.
Kanyika Chamniprasas, D. of Orthopaedic Surgery and Physical Medicine, F. of Medicine, PSU.
Corresponding e-mail : bboonsin@ratree.psu.ac.th

Published : The J of The Orthop ASS 2000, 13(1) : 34-36
Key words : MRSA organism, antibiotic cement

Antibiotic cements have been approved for their efficacy and effectiveness for treatment of orthopaedic infections, especially chronic osteomyelitis, which is caused mostly by gram positive bacteria such as staphylococcus aureus. However, the incidence of MRSA (methicillin-resistant staphylococcus aureus) infection has been increasing recently. This study aimed to compare in vitro elution characteristic of homemade antibiotic cement (fosfomycin, vancomycin and cefalexin) with commercial bead (Septopal) on MRSA organism by disc diffusion technique at various timepoints. The results showed that Septopal and cefalexin cannot inhibit growth of this organism, while fosfomycin and vancomycin had this effect after or for about one month. The inhibition effect was significantly higher in fosfomycin than in vancomycin during the first two weeks. The variability of vancomycin beads was more pronounced than that of fosfomycin beads. In conclusion, homemade fosfomycin and vancomycin cement can effectively inhibit growth of MRSA organisms in the in vitro study.

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