In Vitro inhibitive effect of antibiotic beads to common orthopaedic
pathogens : Home-made vs commercial beads
Boonsin Buranapanitkit, Asst. Prof., D. of Orthopaedic Surgery and Physical Medicine,
F. of Medicine, PSU.
Suntorn Wongsiri, D. of Orthopaedic Surgery and Physical Medicine, F. of Medicine, PSU.
Natnicha Ingviya, Microbiology Unit, D. of Pathology, F. of Medicine, PSU.
Kanyika Chamniprasas, D. of Orthopaedic Surgery and Physical Medicine, F. of Medicine, PSU.
Sineenart Kalnauwakul, Asst. Prof., D. of Pathology, F. of Medicine, PSU.
Corresponding e-mail : bboonsin@ratree.psu.ac.th
Published : The Thai J of Orthop Surg 2000, 25(2) : 48-52
Key words : antibiotic beads, inhibitive effect
Local antibiotic beads have been approved for standard treatment of orthopaedic infection, especially chronic osteomyelitis. Septopal Ò, the only commercial local antibiotic bead available on
the market, is expensive and contains only gentamicin. This study aimed to compare the in vitro inhibitive effect of home-made antibiotic beads (fosfomycin, vancomycin and cefalexin) with SeptopalÒ for common orthopaedic pathogens (Staphylococcus aureus, Pseudomonas aeruginosa)
by disc diffussion technique at various time points. The results showed that Septopal Ò could inhibit S.aureus better than P.aeurginosa. The inhibitive effect prolonged more than one month. Home-made antibiotic beads can inhibit S.aureus, but not for P.aeruginosa. The effect was significantly less than those of SeptopalÒ. Among the home-made antibiotic beads, fosfomycin had more inhibitive effect
than cefalexin and vancomycin. The variability of the inhibitive effect was more pronounced in home-made antibiotic beads than in SeptopalÒ.
In conclusion, this study demonstrated that SeptopalÒ can inhibit common orthopaedic pathogens better than home-made antibiotic beads in vitro study.
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