Comparative bioavailability study of cephalexin monohydrate
การศึกษาเปรียบเทียบค่าชีวประโยชน์ของยาเซฟาเลกซินโมโนฮัยเดรต
Supong Akesiripong, F. of Pharmacy, Huachiew Chalermprakiet U., Samut Prakan
Chaveewan Ratanajamitara, D. of Clinical Pharmacy, F. of Pharmaceutical Sci., PSU.
Wichan Janwittayanuchit, F. of Pharmacy, Huachiew Chalermprakiet U., Samut Prakan
Corresponding e- mail : rchaveew@ratree.psu.ac.th
Grant : Medline Co. Ltd.
Published : Thai J of Hospital Pharm, 1999, 9(2) : 115-122.
Key words : bioavailability, cephalexin, crossover study, HPLC technique,
pharmacokinetic parameters, AUC, Cmax , tmax , concentration-time profile
A comparative bioavailability study of two brands of 500 mg cephalexin capsules was per-formed in 12 healthy Thai male volunteers. A crossover study was selected, using a single dose of
500 mg capsule of both brands. Plasma concentration of cephalexin was determined by HPLC technique. Relevant pharmacokinetic parameters were analyzed and compared between the two
brand names. Results revealed that AUC, Cmax and tmax obtained from concentration-time profiles of both products, were not significantly different (p> 0.1).
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