Comparative bioavailability study of drotaverine hydrochloride
การศึกษาเปรียบเทียบค่าชีวประโยชน์ของยาโดรทาเวอร์รีนไฮโดรคลอไรด์

Supong Akesiripong, F. of Pharmacy, Huachiew Chalermprakiet U., Samut Prakan
Wichan Janwittayanuchit, F. of Pharmacy, Huachiew Chalermprakiet U., Samut Prakan
Chaveewan Ratanajamitara, D. of Clinical Pharmacy, F. of Pharmaceutical Sci., PSU.
S. Juthong, F. of Medicine, PSU.
Corresponding e- mail : rchaveew@ratree.psu.ac.th

Grant : Medline Co. Ltd.
Published : HCU Journal, 1999, 3(5) : 7-12.
Key words : bioavailability, drotaverine hydrochloride

A comparative bioavailability study of two brands of 40 mg Drotaverine tablets was performed in 12 healthy Thai male volunteers. A crossover study was selected, using a single dose of 80 mg (2 tablets) of both brands. Plasma concentration of drotaverine was determined by HPLC technique. Relevant pharmacokinetic parameters were analyzed and compared between the two brand names. Results revealed that AUC, C_max and T_max obtained from concentration-time profiles of both products, were not significantly different (p>0.1). This study showed that both brands were bioequivalent in terms of rate and extent of absorption.

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